Journal
GENES & DEVELOPMENT
Volume 22, Issue 10, Pages 1325-1330Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.469408
Keywords
integrin activation; Kindlin-2; adhesion; mouse development; embryonic stem cells
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Funding
- NIDDK NIH HHS [R01 DK069921, R01 DK69921, P01 DK65123, P01 DK065123] Funding Source: Medline
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Control of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-implantation lethality caused by severe detachment of the endoderm and epiblast from the basement membrane. We found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindlin-2 is required for talin-induced integrin activation. Furthermore, we demonstrate that Kindlin-2 is required for integrin outside-in signaling to enable firm adhesion and spreading. Our findings provide evidence that Kindlin-2 is a novel and essential element of bidirectional integrin signaling.
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