Journal
GENES & DEVELOPMENT
Volume 22, Issue 8, Pages 970-975Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1669408
Keywords
piwi; piRNA; retrotransposon; DNA methylation; spermatogenesis
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Germline genomic methylation is essential for gamete identity and integrity in mammals. The study by Kuramochi-Miyagawa and colleagues (pp. 908-917) in the previous issue of Genes & Development links the process of DNA methylation-dependent repression of retrotranspons with the presence of piwi-interacting RNAs (piRNAs) in fetal male germ cells undergoing de novo methylation.
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