Journal
GENERAL HOSPITAL PSYCHIATRY
Volume 35, Issue 2, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.genhosppsych.2012.06.007
Keywords
Schizophrenia; Behcet's disease; Azathioprine; Agranulocytosis; Immunosuppression
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Behcet's disease (BD) is a recurrent inflammatory disorder involving multisystems of the body. Neuropsychiatric symptoms, like psychosis and depression, often occur in BD, but the safety and efficacy of combined clozapine-azathioprine treatment have never been assessed. We here report on a 37-year-old man with BD and treatment-resistant schizophrenia who obtained an improvement following the introduction of clozapine in addition to azathioprine, without developing agranulocytosis or other severe adverse side effects during a 2-year follow-up. (C) 2013 Elsevier Inc. All rights reserved.
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