Journal
GENERAL AND COMPARATIVE ENDOCRINOLOGY
Volume 208, Issue -, Pages 49-56Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2014.08.016
Keywords
Adipokinetic hormone; Flesh fly; Anautogeny; Digestion; Neuropeptidomics
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Funding
- Flemish government
- FWO-Flanders [G.0405. 09N10]
- KU Leuven Research Foundation [GOA/11/002]
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Females of anautogenous flesh flies, Sarcophaga crassipalpis, need a protein meal in order to produce their first batch of eggs. This protein meal elicits an increase in midgut proteolytic activity that is under neuropeptidergic regulation. Time series of decapitation and rescue experiments of liver fed flies evidenced the need of a peptide factor released by corpora cardiaca (CC) within 4 h post protein feeding in order to assure complete protein digestion. Q-Exactive quantitative differential peptidomics analysis on CC of sugar fed flies and flies 5 h post protein feeding respectively, showed a unique consistent decrease in the stored amount of adipokinetic hormone (AKH) ranging between 16% up to 63%. Injection of AKH into liver fed decapitated flies as well as sugar fed intact flies resulted in dose dependent enhanced midgut proteolytic activity up to the level of intact protein fed flies. This suggests a key role of AKH in food depended reproduction. (C) 2014 Elsevier Inc. All rights reserved.
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