Journal
GENERAL AND COMPARATIVE ENDOCRINOLOGY
Volume 163, Issue 3, Pages 278-284Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2009.04.021
Keywords
Life history; Alternative reproductive tactics; Migration; Microarrays; Gene expression; Gene-expression signature; Ecological genomics; Module
Categories
Funding
- FQRNT
- NSERC
- Atlantic Salmon Federation
- US Forest Service, Northern Research Station
- Bauer Center for Genomics Research
- National Institutes of Health [GM068763]
- Institute for Molecular & Cellular Biology at UT Austin
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How genomic expression differs as a function of life history variation is largely unknown. Atlantic salmon exhibits extreme alternative life histories. We defined the gene-expression signatures of wild-caught salmon at two different life stages by comparing the brain expression profiles of mature sneaker males and immature males, and early migrants and late migrants. In addition to life-stage-specific signatures, we discovered a surprisingly large gene set that was differentially regulated-at similar magnitudes, yet in opposite direction-in both life history transitions. We suggest that this co-variation is not a consequence of many independent cellular and molecular switches in the same direction but rather represents the molecular equivalent of a physiological shift orchestrated by one or very few master regulators. (C) 2009 Elsevier Inc. All rights reserved.
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