Journal
GENE THERAPY
Volume 19, Issue 6, Pages 606-612Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gt.2012.36
Keywords
gene transfer; congestive heart failure; adenylyl cyclase; LV contractility; Ca2+ handling
Categories
Funding
- American Heart Association
- National Institute of Health [P01 HL66941, HL088426, HL081741]
- Department of Veterans Affairs
Ask authors/readers for more resources
Congestive heart failure is an inexorable disease associated with unacceptably high morbidity and mortality. Preclinical results indicate that gene transfer using various proteins is a safe and effective approach for increasing function of the failing heart. In the current review, we provide a summary of cardiac gene transfer in general and summarize findings using adenylyl cyclase 6 as therapeutic gene in the failing heart. We also discuss the potential usefulness of a new treatment for congestive heart failure, paracrine-based gene transfer. Gene Therapy (2012) 19, 606-612; doi:10.1038/gt.2012.36; published online 26 April 2012
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available