Journal
GENE THERAPY
Volume 18, Issue 12, Pages 1127-1133Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gt.2011.56
Keywords
siRNA; drug; liposome; nanoparticle; aptamer
Categories
Funding
- Alon Foundation
- European Union
- Levy Family Trust
- ISF [181/10]
- US Department of Defense
- BSF [2009107]
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Harnessing RNA interference using small RNA-based drugs has great potential to develop drugs designed to knock down expression of any disease-causing gene, thereby greatly expanding the universe of possible drug targets. However, delivering small RNAs into specific tissues and cells is still a hurdle. Here, we review recent progress in overcoming systemic, local and cellular barriers to RNA drug delivery, focusing on strategies for targeted uptake. Gene Therapy (2011) 18, 1127-1133; doi:10.1038/gt.2011.56; published online 14 April 2011
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