Journal
GENE THERAPY
Volume 19, Issue 3, Pages 347-353Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gt.2011.95
Keywords
gold nanoparticle-oligonucleotide complexes; gene delivery; gene expression; signaling pathways; immune activation
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Funding
- National Institutes of Health
- National Science Foundation
- United Kingdom Medical Research Council
- International Institute for Nanotechnology within Northwestern University
- Institute for BioNanotechnology in Medicine
- Engineering and Physical Sciences Research Council [836374] Funding Source: researchfish
- Medical Research Council [G1000196, G0401570] Funding Source: researchfish
- MRC [G0401570, G1000196] Funding Source: UKRI
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The unique properties of oligonucleotide (and small interfering RNA)-modified gold nanoparticle conjugates make them promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findings have strong implications for the application of oligonucleotide-modified gold nanoparticle conjugates in translational research and in the development of therapeutics and gene delivery systems. Gene Therapy (2012) 19, 347-353; doi:10.1038/gt.2011.95; published online 23 June 2011
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