Journal
GENE EXPRESSION PATTERNS
Volume 10, Issue 1, Pages 9-15Publisher
ELSEVIER
DOI: 10.1016/j.gep.2009.11.005
Keywords
Auts2; Gene expression; Patterning; Neurodevelopment; Autism
Categories
Funding
- National Institutes of Health [R01 NS050248]
- Universita' degli Studi di Milano
- Heart and Stroke Foundation of Canada
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS050248] Funding Source: NIH RePORTER
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Autism susceptibility candidate 2 (Auts2) is a gene associated with autism and mental retardation, whose function is unknown. Expression of Auts2 mRNA and protein were studied in the developing mouse brain by in situ hybridization, immunohistochemistry, and western blotting. Auts2 mRNA was highly expressed in the developing cerebral cortex and cerebellum, regions often affected by neuropathological changes in autism, and a few other brain regions. On embryonic day (E) 12, Auts2 mRNA was expressed in the cortical preplate, where it colocalized with Tbr1, a transcription factor specific for postmitotic projection neurons. From E 16 to postnatal day 2 1, Auts2 was expressed most abundantly in frontal cortex, hippocampus and cerebellum, including Purkinje cells and deep nuclei. High levels of Auts2 were also detected in developing dorsal thalamus, olfactory bulb, inferior colliculus and substantia nigra. Auts2 protein showed similar regional expression patterns as the mRNA. At the cellular level, Auts2 protein was localized in the nuclei of neurons and some neuronal progenitors. (C) 2009 Elsevier B.V. All rights reserved
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