Journal
GENE EXPRESSION PATTERNS
Volume 9, Issue 4, Pages 215-223Publisher
ELSEVIER
DOI: 10.1016/j.gep.2008.12.009
Keywords
Limb development; Chondrogenesis; Growth plate; Wnt; Sfrp; Frzb; Dkk; Wisp; Wif1
Categories
Funding
- Deutsche Forschungsgerneinschaft [SFB 577]
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Wnt signalling plays important roles in patterning and outgrowth of the vertebrate limb. Different mutations in Wnt genes, their antagonists or (co-)receptors result in patterning and outgrowth defects as well as chandrocyte and bone phenotypes in mouse and human. Understanding Wnt activity during mouse limb development and chondrogenesis requires a temporal and spatial overview of Wnt signalling key factor expression. Here we present a comparative expression analysis of all 19 Writ genes and their major secreted antagonists of the Dickkopf (Dkk), Wisp and the secreted frizzled related protein (Sfrp) families during mouse limb development. Our study reveals new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb. We also identified novel expression domains for the Wnt antagonists Sfrp1, Sfrp3, Sfrp5, Wisp1 as well as Dkk2 and Dkk3. We provide a full expression pattern for Wif1 in limb development, for which no limb expression had been documented so far. (c) 2009 Elsevier B.V. All rights reserved.
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