Journal
GENE
Volume 679, Issue -, Pages 232-240Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2018.09.011
Keywords
Lung cancer; Hyperoside; Proliferation; Let-7a-5p; CCND1
Categories
Funding
- National Natural Science Foundation of China [31501149, 31770815, 31570764]
- Hubei Provincial Natural Science Foundation [2017CFB537]
- Educational Commission of Hubei Province [B2017009]
- Hubei Province health and family planning scientific research project [WJ2017M173]
- Science and Technology Young Training Program of the Wuhan University of Science and Technology [2016xz035, 2017xz027]
- Wuhan University of Science and Technology [JCX2016024, JCX2017032, JCX2017033]
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Lung cancer remains one of the most aggressive human malignancies with a low survival rate. Hyperoside (quercetin 3-O-beta-D-galactopyranoside) is a flavonol glycoside with an anti-cancer activity. The microRNA-let-7 was widely regarded as a tumor suppressor in human tumors. Here, we investigated the role of hyperoside and let-7a-5p on the lung cancer cell proliferation, cell cycle and apoptosis in A549 cells in vitro. Our results showed that hyperoside could inhibit the proliferation of A549 cells through inducing apoptosis and G1/S phase arrest. Let-7a-5p could inhibit the proliferation of A549 cells via inhibiting the process of G1/S phase. Additionally, hyperoside and let-7a-5p had a synergetic effect on suppressing the proliferation of A549 cells; microRNA-let-7a-5p directly regulated the expression of CCND1 in A549 cells. Our study illustrated that hyperoside and microRNA-let7a-5p might provide a synergistic effect on anti-cancer, which may provide a new idea for lung cancer treatment.
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