Journal
GENE
Volume 533, Issue 1, Pages 385-388Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2013.08.051
Keywords
TLR9 gene; SLE; Polymorphism; Association study; Northern Chinese Han
Categories
Funding
- Heilongjiang Provincial Education Department [12521355]
Ask authors/readers for more resources
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease, with multiple genetic and environmental factors involving in its etiology. The toll-like receptor 9 (TLR9) gene has been reported to have important roles in the development and progression of SLE. We performed a case-control study to investigate the effects of 4 SNPs in the TLR9 gene in the development of SLE in Northern Chinese population. Methods: Four SNPs including rs187084, rs5743836, rs352139 and rs352140 were genotyped using the SNaP-shot method. A group of 430 SLE patients were compared to 424 normal controls. Data were analyzed by SPSS 17.0 and HaploView v 4.1 software. Results: The frequency distributions of SNP rs351240 and haplotype H2 (TGCT) and H3 (CATT) were found to differ significantly between patient and control groups (p < 0.05), while other SNPs and haplotypes showed no significant difference between the two cohorts (p> 0.05). Conclusion: The results revealed that variations in the TLR9 gene are associated with SLE, indicating that TLR9 may play an important role in the pathogenesis of SLE in the northern Chinese Han population. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available