Journal
GENE
Volume 526, Issue 2, Pages 61-74Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2013.05.008
Keywords
EPHX2; Epoxyeicosatrienoic acid; Lipid signaling; Inflammation; Hypertension
Categories
Funding
- NIEHS [R37 ES02710]
- NIH T32 training grant in basic and translational cardiovascular science [T32 HL86350]
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Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules, including the epoxyeicosatrienoic acids (EETs), epoxidized lipids produced from arachidonic acid by the action of cytochrome p450s. Through its metabolism of the EETs and other lipid mediators, sEH contributes to the regulation of vascular tone, nociception, angiogenesis and the inflammatory response. Because of its central physiological role in disease states such as cardiac hypertrophy, diabetes, hypertension, and pain sEH is being investigated as a therapeutic target. This review begins with a brief introduction to sEH protein structure and function. sEH evolution and gene structure are then discussed before human small nucleotide polymorphisms and mammalian gene expression are described in the context of several disease models. The review ends with an overview of studies that have employed the sEH knockout mouse model. (c) 2013 Elsevier B.V. All rights reserved.
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