Journal
GENE
Volume 525, Issue 2, Pages 208-216Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2013.03.057
Keywords
Nucleic acid delivery; Exosome; Liposome; Virus; Progenitor cell; Tumor targeting
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Among innovative strategies developed for cancer treatments, gene therapies stand of great interest despite their well-known limitations in targeting, delivery, toxicity or stability. The success of any given gene-therapy is highly dependent on the carrier efficiency. New approaches are often revisiting the mythic trojan horse concept to carry therapeutic nucleic acid, i.e. DNAs, RNAs or small interfering RNAs, to pathologic tumor site. Recent investigations are focusing on engineering carrying modalities to overtake the above limitations bringing new promise to cancer patients. This review describes recent advances and perspectives for gene therapies devoted to tumor treatment, taking advantage of available knowledge in biotechnology and medicine. (C) 2013 Elsevier B.V. All rights reserved.
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