Journal
GENE
Volume 515, Issue 1, Pages 110-116Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2012.11.019
Keywords
Methionine sulfoxide reductase (Msr); Oxidative stress; Protein oxidation; Ciliate macronuclear genes
Categories
Funding
- Programma Nazionale di Ricerche in Antartide (PNRA)
- Progetti di Ricerca di Interesse Nazionale (PRIN)
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Genes encoding the enzyme methionine sulfoxide reductase type B, specific to the reduction of the oxidized methionine-R form, were characterized from the expressed (macronuclear) genome of two ecologically separate marine species of Euplotes, i.e. temperate water E. raikovi and polar water E. nobilii. Both species were found to contain a single msrB gene with a very simple structural organization encoding a protein of 127 (E. raikovi) or 126 (E. nobilii) amino acid residues that belongs to the group of zinc-containing enzymes. Both msrB genes are constitutively expressed, suggesting that the MsrB enzyme plays an essential role in repairing oxidative damages that appear to be primarily caused by physiological cell aging in E. raikovi and by interactions with an O-2 saturated environment in E. nobilii. (C) 2012 Elsevier B.V. All rights reserved.
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