Journal
GENE
Volume 508, Issue 2, Pages 229-232Publisher
ELSEVIER
DOI: 10.1016/j.gene.2012.07.059
Keywords
Colorectal cancer; Inflammation; PD-1; SNP
Categories
Funding
- Shiraz Institute for Cancer Research
- Shiraz University of Medical Sciences [88-01-01-1402]
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Programmed death-1 (PD-1), expressed by activated T cells, is a negative regulator of T lymphocytes. The associations of the immune response-related genes with cancer have been demonstrated. In this study, the PD-1.5 C/T (+7785) polymorphism was investigated in 200 colorectal cancer patients and 200 healthy individuals as controls by nested polymerase chain reaction-restriction fragment length polymorphism method. The genotype and allele frequencies at PD-1.5 position were not significantly different between control individuals and the overall colorectal cancer patients. However, subdivision of the patients by the location (175 colon cancer and 25 rectal cancer) revealed a significant difference between colon cancer patients and healthy individuals (p = 0.026). and between colon and rectal cancer patients (p = 0.017). The frequency of the CT genotype was significantly higher in colon cancer patients than in control individuals (58.3% vs. 44.8%. Bonferroni corrected p-value = 0.024; OR = 1.74; 95% CI = 1.15-2.62), and in rectal cancer patients (58.3% vs. 28.0%, Bonferroni corrected p-value=0.012; OR = 3.59; 95% CI = 1.42-9.04). Characteristics of the patients including age, sex, tumor grade and stage were not associated with the PD-1.5 polymorphism. Our results show a significant association between PD-1.5 polymorphism and colon cancer. Larger numbers of patients are required to investigate comprehensively the association of rectal cancer with PD-1.5 polymorphism. (C) 2012 Elsevier B.V. All rights reserved.
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