Journal
GENE
Volume 493, Issue 1, Pages 44-51Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2011.11.028
Keywords
miR-421; Biliary malignancy; Tumor suppressor gene; Gallbladder cancer; Cholangiocarcinoma; Cell cycle arrest
Categories
Funding
- National Natural Science Foundation of China [81170426]
- Heilongjiang Provincial Natural Science Foundation of China [ZJY0704-01, QC2010103]
Ask authors/readers for more resources
MicroRNAs (miRNAs) are involved in the development of most cancers. However, few studies have been conducted to determine their relationship to biliary tract cancer (BTC). Farnesoid X receptor (FXR) has been reported to be a tumor suppressor for hepatocellular carcinoma and breast cancer; but few studies have focused on its correlation with BTC. In this study, we identified miR-421 as a potential regulator of FXR expression. We found that their expression amount was inversely correlated as FXR was aberrantly down-regulated in both primary tumor specimens and cell lines; while miR-421 was significantly up-regulated. Ectopic expression of miR-421 significantly decreased FXR protein concentration in BIC cells and promoted cell proliferation, colony formation and migration in vitro. Furthermore, a decrease in miR-421 expression induced G(0)/G(1) cell cycle arrest. In conclusion, our study identified microRNA-421 functions as an oncomiR in BTC by targeting FXR. This finding may provide a novel therapeutic strategy for treatment of biliary tract cancer. (C) 2011 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available