Journal
GENE
Volume 473, Issue 2, Pages 57-66Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2010.11.006
Keywords
Cilia; Flagella; Sinusitis; Male infertility; Hydrocephalus; Situs inversus
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Funding
- March of Dimes [6-FY07-397]
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Motile cilia and flagella are organelles that, historically, have been poorly understood and inadequately investigated. However, cilia play critical roles in fluid clearance in the respiratory system and the brain, and flagella are required for sperm motility. Genetic studies involving human patients and mouse models of primary ciliary dyskinesia over the last decade have uncovered a number of important ciliary proteins and have begun to elucidate the mechanisms underlying ciliary motility. When combined with genetic, biochemical, and cell biological studies in Chlamydomonas reinhardtii, these mammalian genetic analyses begin to reveal the mechanisms by which ciliary motility is regulated. (C) 2010 Elsevier B.V. All rights reserved.
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