Journal
GENE
Volume 434, Issue 1-2, Pages 50-55Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2008.12.013
Keywords
Hub proteins; Human; Non-hub proteins; Protein-protein interactions network; Protein complex; Structural disorderness
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Funding
- Department of Biotechnology, Govt. of India
- Council of Scientific and Industrial Research
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It has been claimed that proteins with more interacting partners (hubs) are structurally more disordered and have a slow evolutionary rate. Here, in this paper we analyzed the evolutionary rate and structural disorderness of human hub and non-hub proteins present/absent in protein complexes. We observed that both non-hub and hub proteins present in protein complexes, are characterized by high structural disorderness. There exists no significant difference in average evolutionary rate of complex-forming hub and non-hub proteins while we have found a significant difference in the average evolutionary rate between hub and non-hub proteins which are not present in protein complexes. We concluded that higher disorderness in complex forming non-hub proteins facilitates higher number of interactions with a large number of protein subunits. High interaction among protein subunits of complex forming non-hub proteins imposes a selective constraint on their evolutionary rate. (c) 2008 Elsevier B.V. All rights reserved.
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