Journal
GENE
Volume 443, Issue 1-2, Pages 64-69Publisher
ELSEVIER
DOI: 10.1016/j.gene.2009.05.009
Keywords
Genetic robustness; Error minimization; Volatility; Codon usage; Natural selection
Categories
Funding
- Human Frontier Science Program Organization
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Selection at the DNA level is usually detected by analysing substitution rates from multiple-species comparisons. It has been suggested that measures of genetic robustness at the codon level, which can be measured by analysing a single coding sequence, can be used to estimate selection. but the validity of these measures has been questioned. Here I test the efficiency of different measures of genetic robustness at the codon level to estimate the level of selection acting on a gene. I find that volatility and other measures of robustness are correlated with dN/dS, and that this is not simply the effect of a preference for translationally optimal codons. I discuss the possible implications and the possible problems of these methods based on single-sequence codon usage analysis. (C) 2009 Elsevier B.V. All rights reserved.
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