Journal
GENE
Volume 411, Issue 1-2, Pages 38-45Publisher
ELSEVIER
DOI: 10.1016/j.gene.2007.12.022
Keywords
LINE-1; alternative splicing; retroelement; gene regulation; mobile elements; RNA processing
Categories
Funding
- NCRR NIH HHS [P20 RR020152, P20 RR020152-04] Funding Source: Medline
- NIA NIH HHS [K01 AG030074] Funding Source: Medline
- NIGMS NIH HHS [R01GM45668, R01 GM045668, R01 GM045668-15] Funding Source: Medline
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LINE-1 elements represent a significant proportion of mammalian genomes. The impact of their activity on the structure and function of the host genomes has been recognized from the time of their discovery as an endogenous source of insertional mutagenesis. L1 elements contain numerous functional internal polyadenylation signals and splice sites that generate a variety of processed L1 transcripts. These sites are also reported to contribute to the generation of hybrid transcripts between L1 elements and host genes. Using northern blot analysis we demonstrate that L1 splicing, but not L1 polyadenylation, is delayed during the course of L1 expression. L1 splicing can also be negatively regulated by EBV SM protein known to alter this process. These results suggest a potential for L1 mRNA processing to be regulated in a tissue- and/or development-specific manner. The delay in L1 splicing may also serve to protect host genes from the excessive burden of L1 interference with their normal expression via aberrant splicing. (C) 2008 Elsevier B.V. All rights reserved.
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