Journal
GASTROINTESTINAL ENDOSCOPY
Volume 80, Issue 1, Pages 97-104Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.gie.2013.12.031
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Background: Both EUS and ERCP sampling techniques may provide tissue diagnoses in suspected malignant biliary obstruction. However, there are scant data comparing these 2 methods. Objective: To compare EUS-guided FNA (EUS-FNA) and ERCP tissue sampling for the diagnosis of malignant biliary obstruction. Design: Prospective, comparative, single-blind study. Setting: Tertiary center. Patients: Fifty-one patients undergoing same-session EUS and ERCP for the evaluation of malignant biliary obstruction over a 1-year period. Interventions: EUS-FNA and ERCP tissue sampling with biliary brush cytology and intraductal forceps biopsies. Main Outcome Measurements: Diagnostic sensitivity and accuracy of each sampling method compared with final diagnoses. Results: EUS-FNA was more sensitive and accurate than ERCP tissue sampling (P<.0001) in 51 patients with pancreatic cancers (n = 34), bile duct cancers (n = 14), and benign biliary strictures (n = 3). The overall sensitivity and accuracy were 94% and 94% for EUS-FNA, and 50% and 53% for ERCP sampling, respectively. EUS-FNA was superior to ERCP tissue sampling for pancreatic masses (sensitivity, 100% vs 38%; P<.0001) and seemed comparable for biliary masses (79% sensitivity for both) and indeterminate strictures (sensitivity, 80% vs 67%). Limitations: Single-center study. Conclusion: EUS-FNA is superior to ERCP tissue sampling in evaluating suspected malignant biliary obstruction, particularly for pancreatic masses. EUS-FNA appears similar to ERCP sampling for biliary tumors and indeterminate strictures. Given the superior performance characteristics of EUS-FNA and the higher incidence of pancreatic cancer compared with cholangiocarcinoma, EUS-FNA should be performed before ERCP in all patients with suspected malignant biliary obstruction.
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