Journal
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
Volume 47, Issue 4, Pages 715-726Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2018.07.001
Keywords
Irritable bowel syndrome; Diet; Dyspepsia; FODMAP; Microbiome; Fiber
Categories
Funding
- NIH [K23 DK101688, R03 DK117219]
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Diet plays a significant role for children with functional abdominal pain disorders. A large majority of these children identify at least 1 food that exacerbates their symptoms. Malabsorbed carbohydrates may have both direct and microbiome-mediated physiologic effects. There are several factors associated with carbohydrate symptom generation, including (1) the amount ingested, (2) ingestion with a meal, (3) small intestinal enzymatic activity, (4) consuming the carbohydrate with microorganisms capable of breaking down the carbohydrate, (5) the gut microbiome, and (6) host factors. Therapies include carbohydrate (single and/or comprehensive) restriction, selective prebiotic and/or enzyme supplementation. Fiber supplementation may also be beneficial.
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