Journal
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
Volume 43, Issue 3, Pages 405-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2014.05.003
Keywords
Immunology; IBD; Biologics; Innate immunity; Adaptive immunity
Categories
Funding
- Inflammatory Bowel Disease Working Group research award
- NIH [R01 AI089714]
- Mayo Research Foundation
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Inflammatory bowel disease (IBD) is an immune-mediated disease and involves a complex interplay of host genetics and environmental influences. Recent advances in the field, including data from genome-wide association studies and microbiome analysis, have started to unravel the complex interaction between host genetics and environmental influences in the pathogenesis of IBD. A drawback of current clinical trials is inadequate or lack of immune phenotyping of patients. However, recent advances in high-throughput technologies provide an opportunity to monitor the dynamic and complex immune system, which may to lead to a more personalized treatment approach in IBD.
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