Journal
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
Volume 42, Issue 1, Pages 133-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2012.11.008
Keywords
Eosinophilic esophagitis; Diagnosis; Treatment; Epidemiology; Endoscopy; Allergy
Categories
Funding
- NIH [1K23 DK090073-01]
- AstraZeneca
- Meritage Pharma
- Olympus
- ACG
- AGA
- CURED Foundation
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Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition whereby infiltration of eosinophils into the esophageal mucosa leads to symptoms of esophageal dysfunction. EoE is encountered in a substantial proportion of patients undergoing diagnostic upper endoscopy. This review discusses the clinical, endoscopic, and histologic features of EoE and presents the most recent guidelines for its diagnosis. Selected diagnostic dilemmas are described, including distinguishing EoE from gastroesophageal reflux disease and addressing the newly recognized clinical entity of proton-pump inhibitor-responsive esophageal eosinophilia. Also highlighted is evidence to support both pharmacologic and nonpharmacologic treatments, including topical corticosteroids, dietary elimination therapy, and endoscopic dilation.
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