Journal
GASTROENTEROLOGY
Volume 146, Issue 3, Pages 647-651Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2013.12.007
Keywords
Early Detection; IPMN; Circulating Tumor Cells; Pancreatic Cancer
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Funding
- National Institutes of Health/National Institute for Diabetes and Digestive and Kidney Diseases [K08DK088945, P30DK050306]
- Pancreatic Cancer Action Network
- Basser Research Center
- National Pancreas Foundation
- Cornell Center for Microenvironment and Metastasis [U54CA143876]
- National Science Foundation [DGE-1144153]
- Friends of Scandinavia
- Sloan Foundation
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Hematogenous dissemination is thought to be a late event in cancer progression. We recently showed in a genetic model of pancreatic ductal adenocarcinoma that pancreas cells can be detected in the bloodstream before tumor formation. To confirm these findings in humans, we used microfluidic geometrically enhanced differential immunocapture to detect circulating pancreas epithelial cells in patient blood samples. We captured more than 3 circulating pancreas epithelial cells/mL in 7 of 21 (33%) patients with cystic lesions and no clinical diagnosis of cancer (Sendai criteria negative), 8 of 11 (73%) with pancreatic ductal adenocarcinoma, and in 0 of 19 patients without cysts or cancer (controls). These findings indicate that cancer cells are present in the circulation of patients before tumors are detected, which might be used in risk assessment.
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