Journal
GASTROENTEROLOGY
Volume 146, Issue 6, Pages 1534-U166Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2014.01.001
Keywords
Cancer; Inflammation; Bacteria
Categories
Funding
- NCI NIH HHS [R01 CA137869, P01 CA116087, CA 77955, CA 116087, R29 CA077955, CA 137869, R01 CA077955] Funding Source: Medline
- NIDDK NIH HHS [DK 58587, R01 DK099076, P30 DK058404, R01 DK058587] Funding Source: Medline
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Microbial species participate in the genesis of a substantial number of malignancies-in conservative estimates, at least 15% of all cancer cases are attributable to infectious agents. Little is known about the contribution of the gastrointestinal microbiome to the development of malignancies. Resident microbes can promote carcinogenesis by inducing inflammation, increasing cell proliferation, altering stem cell dynamics, and producing metabolites such as butyrate, which affect DNA integrity and immune regulation. Studies in human beings and rodent models of cancer have identified effector species and relationships among members of the microbial community in the stomach and colon that increase the risk for malignancy. Strategies to manipulate the microbiome, or the immune response to such bacteria, could be developed to prevent or treat certain gastrointestinal cancers.
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