4.8 Article

Detection of a Sexually Transmitted Hepatitis C Virus Protease Inhibitor-Resistance Variant in a Human Immunodeficiency Virus-Infected Homosexual Man

Journal

GASTROENTEROLOGY
Volume 147, Issue 3, Pages 599-+

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2014.05.010

Keywords

Liver Disease; Cirrhosis; Transmission

Funding

  1. Spanish Ministry of Economy and Competitiveness [BFU2010-15194]
  2. Instituto de Salud Carlos III through the Red Tematica de Investigacion Cooperativa en SIDA (RIS) [RD12/0017]

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There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.

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