Journal
GASTROENTEROLOGY
Volume 142, Issue 4, Pages 730-U129Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2011.12.042
Keywords
Pancreatic Cancer; Tumorigenesis; Transformation; Neoplasm
Categories
Funding
- National Institutes of Health [CA62924, R01CA97075, R01CA120432, RC2CA148376, P01CA134292]
- Stringer Foundation
- Michael Rolfe Foundation
- Lustgarten Foundation for pancreatic cancer research
- German Cancer Aid (Deutsche Krebshilfe e.V.)
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More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms-the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.
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