Journal
GASTROENTEROLOGY
Volume 138, Issue 3, Pages 877-885Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2009.11.044
Keywords
Colorectal; Relative Risk; UPDB
Categories
Funding
- Utah Cancer Registry
- National Cancer Institute's Surveillance, Epidemiology [N01-PC-35141]
- Utah State Department of Health
- University of Utah
- University of Utah Huntsman Cancer Institute.
- National Library of Medicine [R01 LM009331]
- National Cancer Institute [R01-CA40641, PO1-CA73992]
- Intermountain Healthcare Homer Warner Center
Ask authors/readers for more resources
BACKGROUND & AIMS: Colorectal cancer (CRC) risk estimates based on family history typically include only close relatives. We report familial relative risk (FRR) in probands with various combinations, or constellations, of affected relatives, extending to third-degree. METHODS: A population-based resource that includes a computerized genealogy linked to statewide cancer records was used to identify genetic relationships among CRC cases and their first-, second-, and third-degree relatives (FDRs, SDRs, and TDRs). FRRs were estimated by comparing the observed number of affected persons with a particular family history constellation to the expected number, based on cohort-specific CRC rates. RESULTS: A total of 2,327,327 persons included in >= 3 generation family histories were analyzed; 10,556 had a diagnosis of CRC. The FRR for CRC in persons with >= 1 affected FDR = 2.05 (95% CI, 1.96-2.14), consistent with published estimates. In the absence of a positive first-degree family history, considering both affected SDRs and TDRs, only 1 constellation had an FRR estimate that was significantly >1.0 (0 affected FDRs, 1 affected SDR, 2 affected TDRs; FRR = 1.33; 95% CI, 1.13-1.55). The FRR for persons with 1 affected FDR, 1 affected SDR, and 0 affected TDRs was 1.88 (95% CI, 1.59-2.20), increasing to FRR = 3.28 (95% CI, 2.44-4.31) for probands with 1 affected FDR, 1 affected SDR, and >= 3 affected TDRs. CONCLUSIONS: Increased numbers of affected FDRs influences risk much more than affected SDRs or TDRs. However, when combined with a positive first-degree family history, a positive second-and third-degree family history can significantly increase risk.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available