Journal
GASTROENTEROLOGY
Volume 139, Issue 4, Pages 1115-1127Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2010.08.023
Keywords
Drug Safety; Side Effects; Acid Suppressive Therapy
Categories
Funding
- AstraZeneca
- Takeda
- Novartis Consumer
- Xenoport
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Proton pump (H+/K+- adenosine triphosphatase) inhibitors (PPIs) are widely used to treat patients with acid-related disorders because they are generally perceived to be safe and effective. However, as with any pharmacologic agent, they have the potential for side effects. Many studies have examined the side effects of long-term or short-term PPI exposure. We review the mechanism of action of PPIs, focusing on recently released products that might have greater risks of adverse effects than older products because of increased potency and/or duration of action. We summarize the data available on the putative adverse effects of PPI therapy and propose guidelines for clinicians who prescribe these agents to limit the potential for adverse outcomes in users of these effective therapeutic agents.
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