4.6 Article

The Renal Effects of Prenatal Testosterone in Rats

Journal

JOURNAL OF UROLOGY
Volume 193, Issue 5, Pages 1700-1708

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.juro.2014.12.093

Keywords

kidney; androgens; embryonic and fetal development; female; male

Funding

  1. Slovak Research and Development Agency [APVV-0753-10, APVV-0539-12, UK/363/2014]
  2. grant agency of The Ministry of Education of The Slovak Republic [VEGA-1-0406-13]

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Purpose: Previous studies have shown that prenatal testosterone affects the development of not only reproductive organs but also the brain and even glucose metabolism. Whether prenatal testosterone influences the kidney development is largely unknown. We analyzed whether testosterone modulation during prenatal development would affect renal function and the number of nephrons in adult offspring. Materials and Methods: Pregnant rats were treated with olive oil, testosterone (2 mg/kg), the androgen receptor blocker flutamide (5 mg/kg) or testosterone plus flutamide via daily intramuscular injections from gestation day 14 until delivery. Renal histology and functional parameters were assessed in male and female adult offspring. Macerated kidneys were used for nephron counting. Results: Prenatal testosterone administration increased proteinuria in male rats by 256%. A similar 134% effect in female rats was not statistically significant. This effect was prevented when flutamide was co-administered. In male rats prenatal testosterone increased blood urea nitrogen. In female rats flutamide increased creatinine clearance. In male rats prenatal testosterone and flutamide led to higher and lower, respectively, interstitial collagen deposition in adulthood. Conclusions: Prenatal testosterone induces proteinuria in adulthood. This effect is mediated via androgen receptor. Additional effects seem to be sex specific. Further studies should focus on the timing and dosing of testosterone as well as the applicability to human development.

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