Journal
GASTROENTEROLOGIA Y HEPATOLOGIA
Volume 37, Issue 1, Pages 28-34Publisher
ELSEVIER ESPANA SLU
DOI: 10.1016/j.gastrohep.2013.01.008
Keywords
Oxidative stress; Crohn's disease; Catalase
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Crohn's disease (CD) is characterized by transmural inflammation that is most frequently located in the region of the terminal ileum. Although the physiopathological mechanisms of the disease are not yet well defined, the unregulated immune response is associated with high production of reactive oxygen species (ROS). These elements are associated with complex systems known as antioxidant defenses, whose function is ROS regulation, thereby preventing the harmful effects of these elements. However, the presence of an imbalance between ROS production and ROS elimination by antioxidants has been widely described and leads to oxidative stress. In this article, we describe the most significant findings on oxidative stress in the intestinal mucosa and peripheral blood. (C) 2013 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.
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