Journal
FUTURE VIROLOGY
Volume 13, Issue 9, Pages 637-645Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fvl-2018-0055
Keywords
HIV-1; microRNA; naive; nef; PBMC
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Funding
- Iran University of Medical Sciences [9221540201]
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Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV-1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with healthy controls (p < 0.001 for all comparisons). Conclusion: The mentioned miRNAs seem to influence the clinical progression of HIV-1 infection in naive patients. Moreover, determining the profiles of miRNAs involved in the pathogenesis of HIV infection and manipulating these miRNAs could lead to opening a new gate to HIV-1 infection control.
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