Journal
FUTURE VIROLOGY
Volume 9, Issue 1, Pages 53-67Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fvl.13.121
Keywords
antiviral drugdevelopment; dengue virus; Flaviviridae; flaviviruses; hepatitis C virus; plus-strand RNA viruses; protein structure; RNA-dependent RNA polymerases; RNA replication
Categories
Funding
- Infectiopole-Sud
- Fondation pour la Recherche Medicale (Programme Equipe FRM)
- EU [260644]
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Upon the discovery of HCV, dengue virus (DENV) and other flaviviruses have served as models to unravel the biology and mechanisms at play during HCV replication. HCV research has rapidly become a well-established field. Recently, several specific anti-HCV antiviral drugs have been discovered and approved for use in the clinic. Now, the strong emergence of DENV in the world and the associated increasing burden is casting light back to dengue virology and anti-dengue drug discovery.HCV polymerase (NS5B) is a prime target in antiviral therapies, and the analogous DENV polymerase (NS5) is also becoming one. Although both enzymes share common fold and function to some extent, a significant amount of unique structural and functional features have to be clearly delineated to efficiently translate drug design potential between these two essential enzymes.
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