Journal
FUTURE VIROLOGY
Volume 7, Issue 11, Pages 1077-1088Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FVL.12.108
Keywords
cellular immunity; cytotoxic T cells; epitopes; humoral immunity; immunoproteomics; mass spectrometry; MHC class I; vaccine
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Funding
- NIH SBIR from the National Institute of Allergy and Infectious Diseases [IR43AI062177, R43AI091232]
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Prophylactic and therapeutic vaccines against viral infections have advanced in recent years from attenuated live vaccines to subunit-based vaccines. An ideal prophylactic vaccine should mimic the natural immunity induced by an infection, in that it should generate long-lasting adaptive immunity. To complement subunit vaccines, which primarily target an antibody response, different methodologies are being investigated to develop vaccines capable of driving cellular immunity. T-cell epitope discovery is central to this concept. In this review, the significance of T-cell epitope-based vaccines for prophylactic and therapeutic applications is discussed. Additionally, methodologies for the discovery of T-cell epitopes, as well as recent developments in the clinical testing of these vaccines for various viral infections, are explained.
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