Progress towards a universal influenza vaccine

Seasonal influenza is a common and highly transmissible disease, characterized by frequent and unpredictable mutations occurring in the viral envelope glycoproteins. Owing to this high variability, annual reformulation and immunization are required and still, the vaccine is not effective enough when there is an antigenic mismatch with circulating strains. A solution could come from the construction of a universal vaccine that would be based on highly conserved antigens and would be effective against many strains: some universal vaccine developers focus on the Matrix 2 protein, whereas others use additional conserved proteins, such as the nucleoprotein and Matrix 1, or even a range of peptides from these proteins and others to induce cross-strain immunity. This article aims to highlight recent significant advances in the development of a universal vaccine against influenza and focuses mainly on studies using the epitope-based approach that have also entered the clinical trial stage; it includes a brief summary of current vaccines against influenza as well as the ongoing efforts to develop a universal vaccine.