Journal
FUTURE VIROLOGY
Volume 5, Issue 2, Pages 175-183Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FVL.10.3
Keywords
cytotoxic T lymphocytes; dendritic cells; Influenza; vaccination; virus
Categories
Funding
- NIH [AI170251]
- Pfizer
- NHMRC
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI029579, R01AI029579] Funding Source: NIH RePORTER
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Seasonal influenza virus infection is a leading cause of illness and mortality in young children and the elderly each year. Current influenza vaccines generate protective antibody responses; however, these must be given annually to provide protection against serologically distinct viruses, By contrast, CD8(+) T cells are capable of recognizing conserved antigenic determinants within the influenza virion and, as such, may provide protection against a number of variant strains of the virus. CD8(+) T cells play a critical key role in controlling and resolving influenza virus infections via the production of cytokines and cytolytic mediators. This article focuses on the induction of the influenza-specific CD8(+) T-cell response and how these cells acquire and maintain effector function after induction, Moreover, we discuss how cytotoxic T-lymphocyte function correlates with protection following vaccination.
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