4.4 Review

An overview of meningiomas

Journal

FUTURE ONCOLOGY
Volume 14, Issue 21, Pages 2161-2177

Publisher

FUTURE MEDICINE LTD
DOI: 10.2217/fon-2018-0006

Keywords

chemotherapy; imaging; meningioma; molecular pathology; mutations; radiotherapy; stereotactic radiosurgery; surgery; targeted therapy; tumor treating fields

Categories

Funding

  1. SPORE for Translational Approaches to Brain Cancer [P50CA221747]

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Meningiomas are the most common primary intracranial tumor. Important advances are occurring in meningioma research. These are expected to accelerate, potentially leading to impactful changes on the management of meningiomas in the near and medium term. This review will cover the histo- and molecular pathology of meningiomas, including recent 2016 updates to the WHO classification of CNS tumors. We will discuss clinical and radiographic presentation and therapeutic management. Surgery and radiotherapy, the two longstanding primary therapeutic modalities, will be discussed at length. In addition, data from prior and ongoing investigations of other treatment modalities, including systemic and targeted therapies, will be covered. This review will quickly update the reader on the contemporary management and future directions in meningiomas. [GRAPHICS] .

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