Journal
FUTURE ONCOLOGY
Volume 10, Issue 7, Pages 1187-1202Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon.13.263
Keywords
biomarkers; diagnostic; gastric cancer; GDF15; metastasis; miR-200c; MMP7; prognostic
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Funding
- Instituto de Salud Carlos III (Spain) [CA0900116]
- Secretaria Xeral I+D+I (Xunta de Galicia, Spain) [IPP0807]
- Instituto de Salud Carlos III, Spain [PI061541]
- ServizoGalego de Saude, Xunta de Galicia, Spain [PS0877]
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Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed. Patients & methods: Fifty-two GC and 23 control samples were included. Results: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033). Conclusion: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.
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