Journal
FUTURE ONCOLOGY
Volume 9, Issue 9, Pages 1353-1364Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon.13.84
Keywords
anti-tumor effect; apigenin; glucose uptake; GLUT-1; head and neck cancer; PI3K; Akt pathway
Categories
Funding
- Health Department of Zhejiang Province [2010KYA062, 2009B042]
- National Natural Science Foundation of China [81172562]
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Apigenin, a natural phytoestrogen flavonoid, has potential biological effects, including antioxidative, anti-inFLammatory and anticancer activities. The mechanisms of anticancer activities of apigenin are unknown. Some studies have found that apigenin inhibits GLUT-1 mRNA and protein expression in cancer cells. Thus, we hypothesized that apigenin exerts similar effects on head and neck cancers through its inhibition of GLUT-1 expression. In this article, we review the anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers. In addition, we describe the current state of knowledge about the relationship between apigenin and GLUT-1 expression in head and neck cancers.
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