Journal
FUTURE ONCOLOGY
Volume 8, Issue 1, Pages 29-36Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FON.11.128
Keywords
cancer surgery; compartment; embryology; ontogenetic anatomy; tumor invasion
Categories
Funding
- University of Leipzig, Germany
- Leipzig School of Radical Pelvic Surgery
Ask authors/readers for more resources
The pathophysiologic process of local tumor spread is regarded as an isotropic infiltration of microscopic extensions of the malignant lesion irrespective of tissue boundaries. By contrast, the ontogenetic compartment theory states that malignant solid tumors are locally confined, for a relatively long phase during their natural course, to a permissive compartment derived from a common primordium in embryonic development. Tumor permeation is isotropic within the permissive ontogenetic compartment, but it is suppressed at the compartment borders. The validity of the ontogenetic compartment theory has been shown for cancer of the rectum and of the female lower genital tract. It is hypothesized that ontogenetic compartment resection, the translation of the theory into cancer surgery, holds a great potential to improve oncologic treatment results.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available