Journal
FUTURE ONCOLOGY
Volume 6, Issue 12, Pages 1863-1881Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FON.10.142
Keywords
cancer; catecholamine; metastasis; signaling pathway; stress
Categories
Funding
- National Cancer Institute (NCI) [CA110793, CA109298, CA140933, CA104825, U54CA151668]
- Ovarian Cancer Research Fund Program
- University of Texas MD Anderson Cancer Center [P50 CA083639]
- Gynecologic Cancer Foundation
- Zarrow Foundation
- Marcus Foundation
- Betty Anne Asche Murray Distinguished Professorship
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The influence of psychosocial factors on the development and progression of cancer has been a longstanding hypothesis since ancient times. In fact, epidemiological and clinical studies over the past 30 years have provided strong evidence for links between chronic stress, depression and social isolation and cancer progression. By contrast, there is only limited evidence for the role of these behavioral factors in cancer initiation. Recent cellular and molecular studies have identified specific signaling pathways that impact cancer growth and metastasis. This article provides an overview of the relationship between psychosocial factors, specifically chronic stress, and cancer progression.
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