Journal
FUTURE ONCOLOGY
Volume 6, Issue 10, Pages 1563-1576Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FON.10.121
Keywords
cancer cell clonogen; cancer stem-like cell; cancer stem-like cell dynamics; radioresistance determinant; therapeutic strategy
Categories
Funding
- National Cancer Institute [CA-06294, CA-106451, CA-103830, CA-16672, DE 13157, DAMD 17-02-1-0706, DAMD 17-1-1-0689]
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Based on findings that cancer cell clonogens exhibit stem cell features, it has been suggested that cancer stem-like cells are relatively radioresistant owing to different intrinsic and extrinsic factors, including quiescence, activated radiation response mechanisms (e.g., enhanced DNA repair, upregulated cell cycle control mechanisms and increased free-radical scavengers) and a surrounding microenvironment that enhances cell survival mechanisms (e.g., hypoxia and interaction with stromal elements). However, these radiosensitivity features are probably dynamic in nature and come into play at different times during the course of chemo/radiotherapy, Therefore, different molecularly targeted radiosensitization strategies may be needed at different stages of therapy. This article describes potential sensitization approaches based on the dynamics and changing properties of cancer stem-like cells during therapy.
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