Journal
FUTURE ONCOLOGY
Volume 5, Issue 8, Pages 1113-1127Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FON.09.93
Keywords
E-cadherin; epithelial-mesenchymal transition; genetically engineered mice; heterogeneity; invasion; metastasis; mouse mammary tumors; pathology; snail; spindle cell phenotype
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Funding
- Congressionally Directed Medical Program, Cancer Research Program Breast Cancer Center of Excellence [BC043200]
- National Cancer Institute's Mouse Models of Human Cancers Consortium [U01 CA10549001]
- NIH NCRR Mutant Mouse Regional Resource Center [U42 RR14905]
- NATIONAL CANCER INSTITUTE [U01CA141582, U01CA105490] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [U42RR014905] Funding Source: NIH RePORTER
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Epithelial-mesenchymal transition tumorigenesis In the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms, Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice, This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
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