Journal
FUTURE ONCOLOGY
Volume 5, Issue 1, Pages 51-61Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/14796694.5.1.51
Keywords
histopathology; oral cavity; cancer; outcome following surgery; prognosticators; squamous cell carcinoma
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The recent changes in incidence and prevalence of oral squamous cell carcinoma in relation to gender and age mirror the changing patterns of exposure to tobacco and alcohol, the main etiological agents. Most cases of oral cancer are managed by surgery, often combined with radiotherapy. Histopathological assessment of the resection specimen provides information vital for postoperative management and prognosis. This review considers the full range of histological determinants of outcome in relation to the primary oral tumor and any metastatic involvement of the cervical lymphatic system, together with an outline of more general pat lent factors that may also impact on morbidity and mortality rates.
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