Journal
FUTURE ONCOLOGY
Volume 5, Issue 10, Pages 1631-1640Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FON.09.125
Keywords
adhesion; apoptosis; ErbB2/ErbB3 regulation; ligand; membrane mucin; metastasis; MUC4; post-translational regulation; proteosomal degradation; transcription
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Funding
- NIH [CA52498]
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The membrane mucin MUC4 (human) is abundantly expressed in many epithelia, where it is proposed to play a protective role, and is overexpressed in some epithelial tumors. Studies on the rat homologue, Muc4, indicate that it acts through anti-adhesive or signaling mechanisms. In particular, Muc4/MUC4 serve as a ligand/modulator of the receptor tyrosine kinase ErbB2, regulating its phosphorylation and the phosphorylation of its partner ErbB3 with or without the involvement of the ErbB3 ligand neuregulin. Muc4/MUC4 can also modulate cell apoptosis via multiple mechanisms, both ErbB2 dependent and independent. Muc4/MUC4 expression is regulated by multiple mechanisms, ranging from transcriptional to post-translational. The roles of MUC4 in tumors suggest that it may be valuable as a tumor marker or target for therapy.
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