Journal
FUTURE MICROBIOLOGY
Volume 13, Issue 10, Pages 1117-1128Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2018-0185
Keywords
16S rRNA gene sequencing; acetate; Alzheimer's disease; Drosophila; GC-MS; microbiota; SCFA
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Funding
- National Natural Science Foundation of China [31200804]
- Specialized Research Fund for the Doctoral Program of Higher Education, Ministry of Education, China [20120092120065]
- Fundamental Research Funds for the Central Universities, Southeast University, Ministry of Education, China [2242016K41035]
- Students Research Training Program (SRTP) from Southeast University [201510286106, 201610286130]
- Key Laboratory for Experimental Teratology of the Ministry of Education, Shandong University
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Aim: The aim of present study is to investigate the relationship between gut microbiota and Alzheimer's disease (AD) using Drosophila model. Materials & methods: The microbiota was characterized by Illumina sequencing of 16S rRNA gene. Gas chromatography-mass spectrometer was performed to measure the level of short-chain fatty acids (SCFAs), metabolites of the commensal microbiota. Results: The diversity of the gut microbiota increased in AD Drosophila. As the most enriched bacteria at genus level, the proportions of Acetobacter and Lactobacillus decreased dramatically. Acetate was the most abundant SCFA derived from the dysregulated microbiota and markedly downregulated in AD Drosophila. Conclusion: Our study on Drosophila model suggests that dysregulation of gut microbiota may participate in AD pathogenesis by influencing SCFA level.
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