Related references
Note: Only part of the references are listed.Targeting Type VII/ESX Secretion Systems for Development of Novel Antimycobacterial Drugs
Daria Bottai et al.
CURRENT PHARMACEUTICAL DESIGN (2014)
Pyridomycin bridges the NADH- and substratebinding pockets of the enoyl reductase InhA
Ruben C. Hartkoorn et al.
NATURE CHEMICAL BIOLOGY (2014)
Interferon-gamma release assays for tuberculosis: current and future applications
Muhunthan Thillai et al.
EXPERT REVIEW OF RESPIRATORY MEDICINE (2014)
ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis
J. I. Aguilo et al.
CELLULAR MICROBIOLOGY (2013)
Inhaled therapies, azithromycin and Mycobacterium abscessus in cystic fibrosis patients
Emilie Catherinot et al.
EUROPEAN RESPIRATORY JOURNAL (2013)
Vitamin B12 metabolism in Mycobacterium tuberculosis
Krishnamoorthy Gopinath et al.
FUTURE MICROBIOLOGY (2013)
Progress in targeting cell envelope biogenesis in Mycobacterium tuberculosis
Mary Jackson et al.
FUTURE MICROBIOLOGY (2013)
MprAB Regulates the espA Operon in Mycobacterium tuberculosis and Modulates ESX-1 Function and Host Cytokine Response
Xiuhua Pang et al.
JOURNAL OF BACTERIOLOGY (2013)
Protein Export by the Mycobacterial SecA2 System Is Determined by the Preprotein Mature Domain
Meghan E. Feltcher et al.
JOURNAL OF BACTERIOLOGY (2013)
Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study
Josephine M. Bryant et al.
LANCET (2013)
Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus
Alexandre Pawlik et al.
MOLECULAR MICROBIOLOGY (2013)
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis
Regina Wilson et al.
NATURE CHEMICAL BIOLOGY (2013)
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
Inaki Comas et al.
NATURE GENETICS (2013)
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis
Philip Supply et al.
NATURE GENETICS (2013)
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
Kevin Pethe et al.
NATURE MEDICINE (2013)
Advances in the development of new tuberculosis drugs and treatment regimens
Alimuddin Zumla et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis
Thomas R. Ioerger et al.
PLOS ONE (2013)
Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis
Sumit Chakraborty et al.
SCIENCE (2013)
Whole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular Epidemiological Study
Andreas Roetzer et al.
PLOS MEDICINE (2013)
Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study
Josephine M. Bryant et al.
LANCET RESPIRATORY MEDICINE (2013)
Respiratory Outbreak of Mycobacterium abscessus Subspecies massiliense in a Lung Transplant and Cystic Fibrosis Center
Moira L. Aitken et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)
SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
Kapil Tahlan et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Sterilizing Activities of Novel Combinations Lacking First- and Second-Line Drugs in a Murine Model of Tuberculosis
Kathy Williams et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells
Alessandra Romagnoli et al.
AUTOPHAGY (2012)
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis
Timothy M. Chapman et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway
Robert O. Watson et al.
CELL (2012)
Strong Immunogenicity and Cross-Reactivity of Mycobacterium tuberculosis ESX-5 Type VII Secretion-Encoded PE-PPE Proteins Predicts Vaccine Potential
Fade Sayes et al.
CELL HOST & MICROBE (2012)
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria
Diane Houben et al.
CELLULAR MICROBIOLOGY (2012)
Towards a new tuberculosis drug: pyridomycin - nature's isoniazid
Ruben C. Hartkoorn et al.
EMBO MOLECULAR MEDICINE (2012)
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis
Anca Dorhoi et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
New drugs for the treatment of tuberculosis: hope and reality
J. H. Grosset et al.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2012)
Mycobacterium abscessus: a new antibiotic nightmare
Rachid Nessar et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)
Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41)
Florian P. Maurer et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)
Long-Range Transcriptional Control of an Operon Necessary for Virulence-Critical ESX-1 Secretion in Mycobacterium tuberculosis
Debbie M. Hunt et al.
JOURNAL OF BACTERIOLOGY (2012)
Mycobacterium tuberculosis ESAT-6 Exhibits a Unique Membrane-interacting Activity That Is Not Found in Its Ortholog from Non-pathogenic Mycobacterium smegmatis
Joaquin De Leon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Composition of the type VII secretion system membrane complex
Edith N. G. Houben et al.
MOLECULAR MICROBIOLOGY (2012)
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation
Daria Bottai et al.
MOLECULAR MICROBIOLOGY (2012)
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
Anna E. Grzegorzewicz et al.
NATURE CHEMICAL BIOLOGY (2012)
Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis
Myungsun Lee et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
The ESX-5 Associated eccB5-eccC5 Locus Is Essential for Mycobacterium tuberculosis Viability
Mariagrazia Di Luca et al.
PLOS ONE (2012)
Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death
Roxane Simeone et al.
PLOS PATHOGENS (2012)
Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein
Benjamin Blasco et al.
PLOS PATHOGENS (2012)
The Sec translocase
David J. F. Du Plessis et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)
Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis
Ka-Wing Wong et al.
CELLULAR MICROBIOLOGY (2011)
Increased Virulence of an Epidemic Strain of Mycobacterium massiliense in Mice
Shaobin Shang et al.
PLOS ONE (2011)
Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis
Wanliang Shi et al.
SCIENCE (2011)
The rise and fall of the Mycobacterium tuberculosis genome
Frederic J. Veyrier et al.
TRENDS IN MICROBIOLOGY (2011)
Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents
Kathryn E. A. Lougheed et al.
TUBERCULOSIS (2011)
High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism
Jennifer E. Griffin et al.
PLOS PATHOGENS (2011)
Immunotherapy Markedly Increases the Effectiveness of Antimicrobial Therapy for Treatment of Burkholderia pseudomallei Infection
Katie L. Propst et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome
Bibhuti B. Mishra et al.
CELLULAR MICROBIOLOGY (2010)
Protein export systems of Mycobacterium tuberculosis: novel targets for drug development?
Meghan E. Feltcher et al.
FUTURE MICROBIOLOGY (2010)
The Population Dynamics and Control of Tuberculosis
Christopher Dye et al.
SCIENCE (2010)
Direct Visualization by Cryo-EM of the Mycobacterial Capsular Layer: A Labile Structure Containing ESX-1-Secreted Proteins
Musa Sani et al.
PLOS PATHOGENS (2010)
High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling
Priscille Brodin et al.
PLOS PATHOGENS (2010)
Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants
Stephen V. Gordon et al.
BIOESSAYS (2009)
ESX/type VII secretion systems and their role in host-pathogen interaction
Roxane Simeone et al.
CURRENT OPINION IN MICROBIOLOGY (2009)
Characterization of a Mycobacterium tuberculosis ESX-3 Conditional Mutant: Essentiality and Rescue by Iron and Zinc
Agnese Serafini et al.
JOURNAL OF BACTERIOLOGY (2009)
Pristinamycin-inducible gene regulation in mycobacteria
Francesca Forti et al.
JOURNAL OF BIOTECHNOLOGY (2009)
Antigen Load Governs the Differential Priming of CD8 T Cells in Response to the Bacille Calmette Guerin Vaccine or Mycobacterium tuberculosis Infection
Anthony A. Ryan et al.
JOURNAL OF IMMUNOLOGY (2009)
Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families
Daria Bottai et al.
MOLECULAR MICROBIOLOGY (2009)
Synthetic EthR inhibitors boost antituberculous activity of ethionamide
Nicolas Willand et al.
NATURE MEDICINE (2009)
The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis
Andreas H. Diacon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Non Mycobacterial Virulence Genes in the Genome of the Emerging Pathogen Mycobacterium abscessus
Fabienne Ripoll et al.
PLOS ONE (2009)
Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
M. Sloan Siegrist et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Vadim Makarov et al.
SCIENCE (2009)
High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors
Thierry Christophe et al.
PLOS PATHOGENS (2009)
Systematic Genetic Nomenclature for Type VII Secretion Systems
Wilbert Bitter et al.
PLOS PATHOGENS (2009)
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis
Timothy P. Stinear et al.
GENOME RESEARCH (2008)
Identification of functional Tat signal sequences in Mycobacterium tuberculosis proteins
Justin A. McDonough et al.
JOURNAL OF BACTERIOLOGY (2008)
Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state
Benoit Zuber et al.
JOURNAL OF BACTERIOLOGY (2008)
Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice
Tounkang Sambou et al.
MOLECULAR MICROBIOLOGY (2008)
Secreted transcription factor controls Mycobacterium tuberculosis virulence
Sridharan Raghavan et al.
NATURE (2008)
Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP
Wafa Frigui et al.
PLOS PATHOGENS (2008)
Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure
Christian Hoffmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity
Marien I. de Jonge et al.
JOURNAL OF BACTERIOLOGY (2007)
M-tuberculosis and M-leprae translocate from the phagolysosome to the cytosol in myeloid cells
Nicole van der Wel et al.
CELL (2007)
The type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis
Sarah A. Stanley et al.
JOURNAL OF IMMUNOLOGY (2007)
Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions
Nicolaas C. Gey van Pittius et al.
BMC EVOLUTIONARY BIOLOGY (2006)
The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth
Pablo Fernandez et al.
JOURNAL OF BACTERIOLOGY (2006)
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases β-lactam susceptibility and virulence
Brigitte Saint-Joanis et al.
JOURNAL OF BACTERIOLOGY (2006)
Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis
Sebastien Gagneux et al.
PLOS PATHOGENS (2006)
The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis
SB Walters et al.
MOLECULAR MICROBIOLOGY (2006)
The twin-arginine translocation pathway of Mycobactetium smegmatis is functional and required for the export of mycobacterial β-lactamases
JA McDonough et al.
JOURNAL OF BACTERIOLOGY (2005)
Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis
M. Cristina Gutierrez et al.
PLOS PATHOGENS (2005)
A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis
JA MacGurn et al.
MOLECULAR MICROBIOLOGY (2005)
Mutually dependent secretion of proteins required for mycobacterial virulence
SM Fortune et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
K Andries et al.
SCIENCE (2005)
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6
C Demangel et al.
INFECTION AND IMMUNITY (2004)
A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms
D Portevin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis
KM Guinn et al.
MOLECULAR MICROBIOLOGY (2004)
Genetic requirements for mycobacterial survival during infection
CM Sassetti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue
T Hsu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis
M Braunstein et al.
MOLECULAR MICROBIOLOGY (2003)
Genes required for mycobacterial growth defined by high density mutagenesis
CM Sassetti et al.
MOLECULAR MICROBIOLOGY (2003)
Effect of katG mutations on the virulence of Mycobacterium tuberculosis and the implication for transmission in humans
AS Pym et al.
INFECTION AND IMMUNITY (2002)
Phospholipases C are involved in the virulence of Mycobacterium tuberculosis
C Raynaud et al.
MOLECULAR MICROBIOLOGY (2002)
An essential role for phoP in Mycobacterium tuberculosis virulence
E Pérez et al.
MOLECULAR MICROBIOLOGY (2001)
Massive gene decay in the leprosy bacillus
ST Cole et al.
NATURE (2001)
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
CK Stover et al.
NATURE (2000)
The Tat protein export pathway
BC Berks et al.
MOLECULAR MICROBIOLOGY (2000)
Share Paper
