Journal
FUTURE MICROBIOLOGY
Volume 9, Issue 2, Pages 139-146Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb.13.147
Keywords
antifungal effect; biofilms; Candida species; medicinal flowers; phenolic compounds
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Funding
- FCT, POPH-QREN [SFRH/BD/72742/2010]
- FSE [SFRH/BPD/4609/2008]
- [PEst-OE/AGR/UI0690/2011]
- Fundação para a Ciência e a Tecnologia [PEst-OE/AGR/UI0690/2011] Funding Source: FCT
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Aim: To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against Candida planktonic and biofilm cells. Materials & methods: The MICs were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification of colony-forming units. Results: MIC values demonstrated that gallic acid presented the highest effect against all Candida species. Catechin showed a similar effect against Candida albicans American Type Culture Collection (ATCC) 90028 cells. In addition, gallic acid and quercetin had demonstrated only a minimal effect against Candida species biofilms. Conclusion: Gallic acid affected the growth of the different planktonic Candida species in all concentrations used; still, catechin showed a similar effect against C. albicans ATCC 90028 and Candida glabrata ATCC 2001 cells. In addition, only gallic acid and quercetin demonstrated a slight effect against all Candida species biofilms.
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